Author: Sabahat Zahra Siddiqui, Anam Zahid, Muhammad Athar Abbasi, Aziz-ur-Rehman and Faiz-ul-Hassan Nasim
Publishing Date: 2017
Volume 30 Issue 3
A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides by reacting 4-acetamidobenzenesulfonyl chloride (1) with different alkyl/aralkyl/aryl amines (2a-q) in basic aqueous media under controlled pH to afford -[(Substitutedsulfamoyl) phenyl]acetamides (3a-q) which were confirmed through spectral analysis like FT-IR, EIMS and 1H-NMR. Moreover, the synthesized derivatives were screened against α-Chymotrypsin. The enzyme inhibitory results revealed that most of the synthesized compounds were found to be moderate enzyme inhibitors.
KEYWORDS: 4-Acetamidobenzenesulfonyl chloride, alkyl/aralkyl/aryl amines, N-[(Substitutedsulfamoyl) phenyl] acetamides, spectral characterization, α-Chymotrypsin and Enzyme inhibitory analysis.