Author: Bushra Riaz, Rubab Iftikhar Khan Babar, Shahid Iqbal, Muhammad Ali and Furhan Iqbal
Publishing Date: 2017
Volume 30 Issue 3
Present study was designed to demonstrate the effect ethanolic leaf extract of Thuja orientalis on the learning and memory formation in albino mice. Four week old albino mice were either orally supplemented with 50mg/ml solvent/Kg body weight of Thuja orientalis or with equal volume of saline solution (0.9% NaCl) for seven days. A battery of neurological tests (Elevated plus maze, Rota Rod, light and dark box, open field and novel object recognition test) were applied at the end of dose supplementation. Thuja orientalis leaf extract treated female mice spent significantly les time on rotating rod (P = 0.02) than male treated with saline solution [indicating poor neuromuscular coordination]. While all other neurological test performances varied non significantly (P > 0.05) when compared between Thuja orientalis treated albino mice (of both genders) with their respective control groups indicating a moderate effect of 50mg/ml solvent/Kg body weight of Thuja orientalis on the behavior of young albino mice.
KEYWORDS: Thuja orientalis, Albino mouse, rota rod, open field, elevated plus maze, light dark box, novel object test.