HISTOPATHOLOGICAL AND BIOCHEMICAL ASSESSMENT OF KIDNEY DAMAGE IN ALBINO WISTAR RATS TREATED WITH CYTOTOXIC PLATINUM COMPOUNDS IN COMBINATION WITH 5-FU
Author: Nusrat Bano, Rahila Ikram Publishing Date: 2017 E-ISSN: 1011-601X Volume 30 Issue 5 ABSTRACT: Kidney cells damage and subsequent renal adverse effects with oxaliplatin are less reported phenomena, whereas cisplatin (CDDP, first generation platinum compound) has therapeutic limitations due to renal toxicity. This experimental study reports oxaliplatin (third generation platinum compound) induced direct damage in rat kidney tissues and alterations […]