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1011-601X_2017_30_4

Pakistan Journal of Pharmaceutical Sciences

SYNTHESIS, PHARMACOLOGICAL SCREENING AND COMPUTATIONAL ANALYSIS OF SOME 2-(1H-INDOL-3-YL)-N?-[(UN)SUBSTITUTED PHENYLMETHYLIDENE] ACETOHYDRAZIDES AND 2-(1H-INDOL-3-YL)-N?-[(UN)SUBSTITUTED BENZOYL/2-THIENYLCARBONYL]ACETOHYDRAZIDES

Author: Kaniz Rubab, Muhammad Athar Abbasi, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, Muhammad Ashraf, Qurat-ul-Ain, Irshad Ahmad, Muhammad Arif Lodhi, Mehreen Ghufran, Muhammad Shahid, Hina Fatima Publishing Date: 2017 E-ISSN: 1011-601X Volume 30 Issue 4 ABSTRACT: The undertaken research was initiated by transforming 2-(1H-Indol-3-yl)acetic acid (1) in catalytic amount of sulfuric acid and ethanol to ethyl 2-(1H-Indol-3-yl)acetate (2), which […]

SYNTHESIS, PHARMACOLOGICAL SCREENING AND COMPUTATIONAL ANALYSIS OF SOME 2-(1H-INDOL-3-YL)-N?-[(UN)SUBSTITUTED PHENYLMETHYLIDENE] ACETOHYDRAZIDES AND 2-(1H-INDOL-3-YL)-N?-[(UN)SUBSTITUTED BENZOYL/2-THIENYLCARBONYL]ACETOHYDRAZIDES Read More »

COMPARATIVE ROLE OF PREGABALIN AND CARBAMAZEPINE REGARDING EFFICACY IN PAINFUL DIABETIC NEUROPATHY

Author: Raana Mahmood, Itrat Jawed, M Irfan Khan, Iffat Mahmood, Talat Tariq, Arfa Kamil, Faiza Z Sayeed, Bushra Z Sayeed Publishing Date: 2017 E-ISSN: 1011-601X Volume 30 Issue 4 ABSTRACT: Neuropathic pain is the most severe and resistant type of pain which has impact on quality of life and behaviour; it most commonly occurs at night causing disturbed sleep. Diabetes mellitus

COMPARATIVE ROLE OF PREGABALIN AND CARBAMAZEPINE REGARDING EFFICACY IN PAINFUL DIABETIC NEUROPATHY Read More »

IN VITRO EFFECTS AND THE RELATED MOLECULAR MECHANISM OF GALANGIN AND QUERCETIN ON HUMAN GASTRIC CANCER CELL LINE (SGC-7901)

Author: Yun Xia Xu, Bo Wang, Xin Huai Zhao Publishing Date: 2017 E-ISSN: 1011-601X Volume 30 Issue 4 ABSTRACT: Natural flavonoids are proven to be powerful against various cancers, but few studies have investigated the potential effects of two flavonoids galangin and quercetin on a human gastric cancer cell line (SGC-7901). In vitro growth inhibition and apoptosis of the two flavonoids

IN VITRO EFFECTS AND THE RELATED MOLECULAR MECHANISM OF GALANGIN AND QUERCETIN ON HUMAN GASTRIC CANCER CELL LINE (SGC-7901) Read More »

FORMULATION OF LYOPHILIZED SINGLE VIAL KIT OF N-N-ETHYLENE-L-DICYSTEINE (EC) FOR LABELING WITH 99MTC. II: RADIOCHEMICAL AND CLINICAL EVALUATION AS A RENAL TUBULAR AGENT IN COMPARISON WITH 99MTC-MAG3

Author: Anjum Afshan, Mohammad Sohaib, Mohammad Jehangir Publishing Date: 2017 E-ISSN: 1011-601X Volume 30 Issue 4 ABSTRACT: A Technetium 99mTc labeled lyophilized single component kit of N-N-ethylene-I-dicysteine (EC) is developed to replace multiple step kit developed by others. The aim of study is to formulate a radionuclide that is easy to prepare, has rapid plasma clearance, produce high quality images and

FORMULATION OF LYOPHILIZED SINGLE VIAL KIT OF N-N-ETHYLENE-L-DICYSTEINE (EC) FOR LABELING WITH 99MTC. II: RADIOCHEMICAL AND CLINICAL EVALUATION AS A RENAL TUBULAR AGENT IN COMPARISON WITH 99MTC-MAG3 Read More »

SYNERGISTIC INTERACTIONS OF POLYPHENOLS AND THEIR EFFECT ON ANTIRADICAL POTENTIAL

Author: Saba Aslam, Nazish Jahan, Khalil-Ur-Rahman, Fatiqa Zafar, M Yasin Ashraf Publishing Date: 2017 E-ISSN: 1011-601X Volume 30 Issue 4 ABSTRACT: The aim of the current study was to evaluate interactions among polyphenols from different plants and their effect on antioxidant potential. Different mixtures of plant extracts of Crataegus oxyacantha (C), Elettaria cardamomum (Cr), Terminalia arjuna (T) and Rauvolfia serpentina (R)

SYNERGISTIC INTERACTIONS OF POLYPHENOLS AND THEIR EFFECT ON ANTIRADICAL POTENTIAL Read More »