QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) STUDIES ON NITAZOXANIDE-BASED ANALOGUES AGAINST CLOSTRIDIUM DIFFICILE IN VITRO
Author: Han Zhang, Xiwang Liu, Yajun Yang and Jianyong Li* Publishing Date: 2016 E-ISSN: 1011-601X Volume: 29 Issue: 5 ABSTRACT: Quantitative structure activity relationship (QSAR) has been established between the various physiochemical parameters of a series of nitazoxanide-based analogues and its antibacterial activity against Clostridium difficile. Genetic function approximation (GFA) and comparative molecular field analysis (CoMFA) techniques were used to […]