Author: Aziz-ur-Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Ayesha Mohyuddin, Sohail Nadeem and Syed Adnan Ali Shah
Publishing Date: 2016
Volume 29 Issue 5
New potent organic compounds were synthesized with an aim of good biological activities such as antibacterial and anti-enzymatic. Three series of sulfonamide derivatives were synthesized by treating N-alkyl/aryl substituted amines (2a-f) with 4-chlorobenzensulfonyl chloride (1) to yield N-alkyl/aryl-4-chlorobenzenesulfonamide(3af) that was then derivatized by gearing up with ethyl iodide (4), benzyl chloride (5) and 4-chlorobenzyl chloride (6) using sodium hydride as base to initialize the reaction in a polar aprotic solvent (DMF) to synthesize the derivatives, 7a-f, 8afand 9a-f respectively. Structure elucidation was brought about by IR, 1H-NMR and EIMS spectra for all the synthesized molecules which were evaluated for their antibacterial activities and inhibitory potentials for certain enzymes.
KEYWORDS: 4-Chlorobenzenesulfonyl chloride; amines; sulfonamides; antibacterial activity; enzyme inhibition activity; 1H-NMR and EIMS.