Author: Mohammad Shoaib, Syed Wadood Ali Shah, Shafiullah Shah, Nawaz Khan and Muhammad Naeem Ahmed
Publishing Date: 2017
Volume 30 Issue 6
A novel flavone derivative has been synthesized in good yield from ketone and aldehyde. The structure has been established by different spectroscopic techniques like 1 H NMR, 13C NMR, IR and elemental analysis. The compound was then screened for its acute toxicity and antinociceptive activity studies on animal model. The novel compound was safe upto a maximum dose of 500mg/kg body weight oral dose in mice and showed 65.92 and 82.18% pheriperal analgesic activity at 15 and 30mg/kg body weight doses. Central antinociceptive activity of the compound was 53.13 and 64.44% at 15 and 30mg/kg body weight respectively.
Keywords: Flavonoids, chalcone, flavone, acute toxicity, antinociceptive activity.