Author: Sin Yeang Teow and Syed Atif Ali

Publishing Date: 2017

E-ISSN: 1011-601X

Volume 30 Issue 3


This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus). Minimal inhibitory concentrations (MICs) of Curcumin against S. aureus were statistically indifferent (p>0.05) at pH7.4 and pH6.5. Activity of Curcumin against S. aureus was reduced by two folds in the presence of 1.25-5% BSA/HSA.

KEYWORDS: Curcumin, antibacterial activity, Staphylococcus aureus, plasma protein binding, serum albumin.

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