Author: Ishrat Younus, Afshan Siddiq, Humera Ishaq, Laila Anwer, Sehrish Badar and Muhammad Ashraf
Publishing Date: 2016
E-ISSN: 1011-601X
Volume: 29 Issue: 4
ABSTRACT:
The aim of this study was to evaluate antiviral activity of chloroformic leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus using MTT assay (3-(4, 5- Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Antiviral and cytotoxic activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. The concentrations which resulted in cell survival percentages of greater than 50% are considered to be effective antiviral concentrations. From the tested plant extracts, Moringa oleifera showed potent antiviral activity (p<0.05) while Azadirachta indica showed significant antiviral activity in the range of 1-50μg/ml & 12-100μg/ml respectively. In contrast no antiviral activity was observed by Morus alba as all the tested concentration resulted in significant reduction (p<0.05) in cell survival percentage.
KEYWORDS: Foot and mouth disease virus, plant extract, antiviral activity.