Author: Madiha Ahmed, Abdul Rehman Phul, Ihsan-ul-Haq, Gulnaz Bibi, Kehkashan Mazhar, Tofeeq Ur-Rehman1, Muhammad Zia and Bushra Mirza
Publishing Date: 2016
Volume: 29 Issue: 3
Bergenia ciliata (locally known as Zakhm-e-hayat; wound healer) is commonly employed for wound healing, curing diarrhea and vomiting, fever, cough and pulmonary affections. Local community uses this plant as tea decoction with table salt. B. ciliata crude extract and its fractions were subjected to antibacterial, antioxidant effects as well as determination of total flavonoids and phenolics, DNA damage and anticancerous activities following standard protocols. Increased percentage inhibition of free radical in DPPH assay as well as elevated phenolic and flavonoid contents revealed antioxidant potential of this potent herb. Ethyl acetate and aqueous extracts showed IC50 of 0.7 and 0.3 mg/ml respectively, against H157 cell line. Antibacterial analysis showed MIC 0.4-10mg/ml for crude extract and fractions. The results obtained conclude that extracts of B. ciliata contain remedial latent and can be used as possible source for drug development by pharmaceutical industries.
KEYWORDS: Antibacterial; anticancer; antioxidant; Bergenia ciliata; DNA protection assay.