Author: Sarwat Jahan, Shamim Akhtar, Arfa Kamil, Nousheen Mushtaq, Zafar Saied Saify and Muhammad Arif
Publishing Date: 2016
Volume: 29 Issue: 1
Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.
KEYWORDS: Alkyl piperidine derivatives, analgesic activity, SAR.